在食品和飼料安全、環(huán)境安全、臨床診斷、邊境控制和過程控制等領(lǐng)域，MP-SPR是一種非常有價(jià)值的分析開發(fā)工具。雖然世界范圍內(nèi)的部分研究致力于高通量儀器，但便攜式或即時(shí)診斷設(shè)備越來越受到關(guān)注。MP-SPR是開發(fā)便攜式生物傳感器的優(yōu)秀工具。便攜式生物傳感器通常包括電化學(xué)傳感器、表面增強(qiáng)拉曼傳感器（SER）、酶聯(lián)免疫吸附試驗(yàn)（ELISA）、熒光或最近的印刷診斷。

選擇MP-SPR進(jìn)行分析開發(fā)的五個(gè)原因：

1、SPR傳感器易于非原位修飾
2、任何分析類型
3、任何樣品
4、易于驗(yàn)證
5、微流體材料測試

有關(guān)電化學(xué)生物傳感器開發(fā)的信息，請(qǐng)單擊此處。

MP-SPR可以回答的五個(gè)分析開發(fā)中的關(guān)鍵問題：

1、與表面B相比，分子X與表面A結(jié)合的速度有多快？

2、我的生物傳感器應(yīng)用的最佳表面是什么？

3、我的化驗(yàn)是如何處理諸如血清、唾液、海水或尿液之類的原始樣本的？

4、我設(shè)計(jì)的生物傳感器是否比前一個(gè)更有效？

5、哪種涂層可以防止樣品吸附到我的微流體通道上？

BioNavis_AN#117_使用SPR Navi 200定量分析單鏈寡核苷酸

BioNavis_AN#126_使用MP-SPR研究纖維素模型表面與蛋白質(zhì)的相互作用

BioNavis_AN#131_使用MP-SPR技術(shù)的深掃描光學(xué)現(xiàn)象測定微米尺度層的光學(xué)特性和相互作用

BioNavis_AN#132_通過MP-SPR測定功能層的結(jié)合能力

BioNavis_AN#140_使用MP-SPR測量自組裝金納米粒子

BioNavis_AN#145_使用MP-SPR研究病毒之間的相互作用

BioNavis_AN#150_使用MP-SPR表征有機(jī)膦酸鹽

BioNavis_AN#151_ MP-SPR測量100%血清中納米粒子上的恒定蛋白冠和動(dòng)態(tài)蛋白冠

BioNavis_AN#160_生物傳感器用于檢測奶粉中的細(xì)菌

Selected publications:

For electrochemical sensor development using MP-SPR, click here.

Printed biosensor development using MP-SPR:

• An impedimetric study of DNA hybridization on paper-supported inkjet-printed gold electrodes, Ihalainen P et al., Nanotechnology, 25, 9, 2014
• Application of Paper-Supported Printed Gold Electrodes for Impedimetric Immunosensor Development, Ihalainen P et al., Biosensors 2013, 3, 1-17

MEMS sensor development using MP-SPR:

• Investigation of pH-Induced Protein Conformation Changes by Nanomechanical Deflection, Thakur G et al., Langmuir, 2014, 30 (8), pp 2109–2116

Novel coatings to avoid non-specific binding using MP-SPR:

• Surface Plasmon Resonance on Nanoscale Organic Films, Albers MW and Vikholm-Lundin I, Nano-Bio-Sensing, 1st ed, Chapter 4, Springer 2010
• Grafting hyaluronic acid onto gold surface to achieve low protein fouling in surface plasmon resonance biosensors, Liu X et al, ACS Appl Mater Interfaces. 2014 Aug 13;6(15):13034-42
• Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection, Islam N et al.,  Journal of Physical Chemistry, 2014, 118 (10), pp 5361–5373

Assay development using MP-SPR:

• Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance, Islam N et al., Biosensors and Bioelectronics, 58, 2014, p. 380-387
• Rapid and sensitive detection of maize chlorotic mottle virus using surface plasmon resonance-based biosensor, Zeng C et al., Anal. Biochem. 440 (2013) 18–22
• Development of diagnostic SPR based biosensor for the detection of pharmaceutical compounds in saliva, Sonny S et al., Proc. SPIE 7376, Laser Applications in Life Sciences, 737605
• Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma, Capasso et al., Taylor & Francis Online, 2015

Improving performance of optical biosensors:

• Label-Enhanced Surface Plasmon Resonance: A New Concept for Improved Performance in Optical Biosensor Analysis, Granqvist N et al., Sensors 2013, 13(11), 15348-15363